AUTHOR=Ashida Reiko , Ioka Tatsuya , Takada Ryoji , Fukutake Nobuyasu , Ikezawa Kenji , Ohkawa Kazuyoshi , Nagata Shigenori , Takahashi Hidenori 

TITLE=New Screening System Using Forward-Viewing Radial Endoscopic Ultrasound and Magnetic Resonance Imaging for High-Risk Individuals With Familial History of Pancreatic Cancer

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.928182

DOI=10.3389/fmed.2022.928182

ISSN=2296-858X

ABSTRACT=<sec><title>Background and Aims</title><p>Attention is increasingly being paid to family history of pancreatic cancer (PC) as a risk factor for developing PC. It is mandatory to develop a screening system for early detection of PC; however, the relationship between a family history of PC and the incidence of pancreatic abnormalities, such as pancreatic cyst and chronic pancreatitis (CP), in the Japanese population remains unknown.</p></sec><sec><title>Patients and Methods</title><p>Individuals with a family history of PC were prospectively enrolled in a screening program using forward-viewing radial endoscopic ultrasound (FR-EUS) and magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP) as the diagnostic modalities.</p></sec><sec><title>Results</title><p>In total, forty-three individuals in 37 families were enrolled (mean age, 54 years). All individuals underwent FR-EUS and MRI with no complications. FR-EUS revealed resectable PC (<italic>n</italic> = 1, 2.3%), pancreatic cysts (<italic>n</italic> = 24, 55.8%), intraductal papillary mucinous neoplasm (IPMN; <italic>n</italic> = 13, 30.2%), and early CP-like appearance (<italic>n</italic> = 15, 34.9%). The detection rate of early CP-like appearance was significantly higher by EUS than by MRI. Pancreatic cysts and IPMN detected by FR-EUS were significantly correlated to age (≥60 years) and less correlated to men (hazard ratio [HR] 22.4; 95% confidence interval [CI], 2.10–236.0; <italic>p</italic> &lt; 0.01 and HR 0.092; 95% CI, 0.01–0.83; <italic>p</italic> = 0.033, respectively). Early CP-like appearance detected by FR-EUS was significantly correlated with men and smoking (HR 5.0; 95% CI, 1.3–19.3; <italic>p</italic> = 0.02 and HR 4.02; 95% CI, 0.991–16.3; <italic>p</italic> = 0.05, respectively).</p></sec><sec><title>Conclusion</title><p>A screening system using FR-EUS and MRI/MRCP for individuals with a family history of PC was useful for identifying curable PC and pancreatic abnormalities. The incidence of pancreatic cysts, such as IPMN and early CP-like appearance, was also high in the Japanese cohort.</p></sec>