AUTHOR=Yang Zhe-Yu , Fang Wen-Hui , Kao Chia-Chun , Chen Wei-Liang 

TITLE=Examining the association between serum IgG of oral bacteria and metabolic syndrome

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.899063

DOI=10.3389/fmed.2022.899063

ISSN=2296-858X

ABSTRACT=<sec><title>Aim</title><p>This investigation explored the relationship between oral bacteria and metabolic syndrome (METS).</p></sec><sec><title>Materials and Methods</title><p>There were 4,882 subjects enrolled in this cross-sectional study from the NHANES III database. The severity of periodontitis was classified into mild, moderate and severe. We measured oral bacterial antibodies. We examined the relationship between serum immunoglobulin G (IgG) antibodies of oral bacteria and METS <italic>via</italic> performing multivariate regression analysis. Mediation analysis of oral bacteria on the correlation between periodontitis and METS was also executed.</p></sec><sec><title>Results</title><p>After adjusting for covariates, the serum IgG antibodies of <italic>P. nigrescens, E. corrodens</italic>, and <italic>E. nodatum</italic> were associated with the presence of METS (<italic>p</italic> = 0.006, <italic>p</italic> = 0.014 and <italic>p</italic> = 0.018, respectively). Furthermore, serum IgG antibodies of <italic>P. intermedia, T. forsythia</italic> and <italic>V. parvula</italic> were positively associated with the presence of METS (<italic>p</italic> = 0.001, <italic>p</italic> = 0.011, and <italic>p</italic> = 0.002, respectively) and ≥4 features of METS (<italic>p</italic> = 0.019, <italic>p</italic> = 0.025, and <italic>p</italic> = 0.02, respectively). <italic>P. intermedia</italic> IgG mediated 11.2% of the relationship between periodontitis and METS.</p></sec><sec><title>Conclusion</title><p>Serological markers of oral pathogens were correlated with the presence and the number of METS features after multivariable adjustment. Oral bacteria acted as a mediator of the correlation between periodontitis and METS. Our study provided a biologically plausible explanation for the association between periodontitis and METS, which provides a comprehensive evaluation of periodontitis.</p></sec>