AUTHOR=Lee Jun Young , Chae Jung Ho , Hur Min Goo , Yang Seung Dae , Kong Young Bae , Lee Jongchul , Ju Jin Sik , Choi Pyeong Seok , Park Jeong Hoon 

TITLE=Theragnostic 64Cu/67Cu Radioisotopes Production With RFT-30 Cyclotron

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.889640

DOI=10.3389/fmed.2022.889640

ISSN=2296-858X

ABSTRACT=<p><sup>64</sup>Cu and <sup>67</sup>Cu are theragnostic pair radionuclides with promising application in the nuclear medicine. <sup>64</sup>Cu is PET nuclide for the non-invasive diagnosis and <sup>67</sup>Cu is beta emitter for therapy of various cancers. This study discusses optimization efforts in the production of these radioactive coppers carried out with 30 MeV cyclotron. Optimized conditions include target preparation, chemical separation, and quality control. The production routes of <sup>64</sup>Cu and <sup>67</sup>Cu were studied based on the nuclear reactions of <sup>64</sup>Ni(p,n)<sup>64</sup>Cu and <sup>70</sup>Zn(p,α)<sup>67</sup>Cu. The produced <sup>64</sup>Cu and <sup>67</sup>Cu have &gt;99.9% of the radionuclidic purity. The yield at the end of bombardment (EOB) of <sup>64</sup>Cu and <sup>67</sup>Cu is 28.5 MBq/μAh and <sup>67</sup>Cu is 0.58 MBq/μAh, respectively.</p>