AUTHOR=Balma Michele , Liberini Virginia , Racca Manuela , Laudicella Riccardo , Bauckneht Matteo , Buschiazzo Ambra , Nicolotti Daniele Giovanni , Peano Simona , Bianchi Andrea , Albano Giovanni , Quartuccio Natale , Abgral Ronan , Morbelli Silvia Daniela , D'Alessandria Calogero , Terreno Enzo , Huellner Martin William , Papaleo Alberto , Deandreis Désirée TITLE=Non-conventional and Investigational PET Radiotracers for Breast Cancer: A Systematic Review JOURNAL=Frontiers in Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.881551 DOI=10.3389/fmed.2022.881551 ISSN=2296-858X ABSTRACT=

Breast cancer is one of the most common malignancies in women, with high morbidity and mortality rates. In breast cancer, the use of novel radiopharmaceuticals in nuclear medicine can improve the accuracy of diagnosis and staging, refine surveillance strategies and accuracy in choosing personalized treatment approaches, including radioligand therapy. Nuclear medicine thus shows great promise for improving the quality of life of breast cancer patients by allowing non-invasive assessment of the diverse and complex biological processes underlying the development of breast cancer and its evolution under therapy. This review aims to describe molecular probes currently in clinical use as well as those under investigation holding great promise for personalized medicine and precision oncology in breast cancer.