AUTHOR=Yu Ziqi , Wang Aiyao , Hu Chong , Yu Tao , Chen Jianyong 

TITLE=Type-1 Grade 2 Multi-Focal Gastric Neuroendocrine Tumors Secondary to Chronic Autoimmune Gastritis

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.856125

DOI=10.3389/fmed.2022.856125

ISSN=2296-858X

ABSTRACT=<sec><title>Background</title><p>Chronic autoimmune gastritis (CAG) refers to chronic atrophic gastritis due to autoimmunity. Loss of gastric glands in CAG results in hypergastrinemia and achlorhydria leading to Vitamin B<sub>12</sub> deficiency and hyperplasia of G cells and enterochromaffin-like (ECL) cells. Vitamin B<sub>12</sub> deficiency could cause pernicious anemia and subacute combined degeneration, while G cells and ECL cells hyperplasia might develop gastric neuroendocrine tumor (G-NET).</p></sec><sec><title>Case Presentation</title><p>A 35-year-old Chinese female presented with multi-focal type-1 Grade 2 (G2) NETs with a 14-year history of pernicious anemia and subacute combined degeneration.</p></sec><sec><title>Conclusion</title><p>Here, we report a rare case of a Chinese patient presenting G-NET combined with pernicious anemia and subacute combined degeneration, which are secondary to chronic autoimmune gastritis. This case also illustrates the importance of routine gastroscopy in patients with Vitamin B<sub>12</sub> deficiency.</p></sec>