AUTHOR=Zhou Fang-Yue , Li Yi-Sha , Guo Xingneng , Shi Xiutong , Wu Ke , Zheng Jing-Wei , Li Xia-Xin , Wu Jiaqing , Liu Ruru , Dai Ma-Li , Huang Xiu-Feng , Hou Fang , Lin Dan , Wang Yu-Qin TITLE=Contrast Sensitivity Deficits and Its Structural Correlates in Fuchs Uveitis Syndrome JOURNAL=Frontiers in Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.850435 DOI=10.3389/fmed.2022.850435 ISSN=2296-858X ABSTRACT=Purpose

To investigate the deficits in contrast sensitivity in patients with Fuchs uveitis syndrome (FUS) and to explore the potential relationship between contrast sensitivity and ocular structure.

Methods

In this prospective study, 25 patients with FUS and 30 healthy volunteers were recruited. Eyes were divided into three groups: FUS-affected eyes (AE), fellow eyes (FE), and healthy eyes. The contrast sensitivity function (CSF) of all participants was evaluated using the quick CSF (qCSF) method. Fundus photographs were collected for the analysis of refractive media, and vascular density (VD) was assessed using optical coherence tomography angiography (OCTA). Data were analyzed and compared using the generalized estimating equation (GEE).

Results

The CSF of AE was significantly lower than that of FE and controls, while no significant difference was observed between FE and controls. Contrast sensitivity was negatively correlated with the grade of haze. No significant correlation was found between visual function and VDs in FUS eyes.

Conclusions

We found that the CSF of FUS-affected eyes was significantly reduced, and the visual impairment was predominantly caused by the refractive media turbidity.