AUTHOR=Zhao Yalei , Yang Ya , Li Qian , Li Jianzhou TITLE=Understanding the Unique Microenvironment in the Aging Liver JOURNAL=Frontiers in Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.842024 DOI=10.3389/fmed.2022.842024 ISSN=2296-858X ABSTRACT=

In the past decades, many studies have focused on aging because of our pursuit of longevity. With lifespans extended, the regenerative capacity of the liver gradually declines due to the existence of aging. This is partially due to the unique microenvironment in the aged liver, which affects a series of physiological processes. In this review, we summarize the related researches in the last decade and try to highlight the aging-related alterations in the aged liver.