AUTHOR=Feng Mudan , Lei Lan , Xu Jian , Shi Yuzhi , Yang Wenfeng 

TITLE=Platelet-to-Portal Vein Width Ratio and Platelet-to-Spleen Thickness Ratio Can Be Used to Predict Progressive Liver Fibrosis Among Patients With HBV Infection With HBeAg-Negativity and a Normal ALT Level

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.837898

DOI=10.3389/fmed.2022.837898

ISSN=2296-858X

ABSTRACT=<sec><title>Background</title><p>Some people infected with the hepatitis B virus (HBV) with a normal level of alanine aminotransferase (ALT) are at risk of disease progression. We evaluated the value of platelet-to-portal vein width ratio (PPR) and platelet-to-spleen thickness ratio (PSR) to predict progressive liver fibrosis among patients with HBV infection with HBV e antigen (HBeAg)-negativity and a normal ALT level.</p></sec><sec><title>Methods</title><p>HBV surface antigen (HBsAg)-positive and HBeAg-negative individuals with a normal ALT level were enrolled. The inflammation grade (G) and fibrosis stage(S) were analyzed according to pathological features. Then, two groups (&lt;S2 <italic>vs</italic>. ≥S2) among people with a normal ALT level were divided based on the pathological diagnosis, and the clinical characteristics were summarized.</p></sec><sec><title>Results</title><p>Seventy-three individuals among 142 patients with HBsAg-positivity and HBeAg-negativity had a normal ALT level. Also, 83.56% (61/73) individuals showed progressive liver fibrosis (≥S2). The ALT level and aspartate aminotransferase (AST) between the two groups differed (21.01 ± 7.40 vs. 25.37 ± 7.90 U/L, <italic>p</italic> = 0.08; 29.49 ± 13.56 vs. 30.16 ± 21.88 U/L, <italic>p</italic> = 0.92, respectively). Portal-vein width, serum levels of albumin and globulin, AST-to-Platelet Ratio Index (APRI), and Fibrosis 4 (FIB-4) score were not significantly different between the two groups (<italic>p</italic> &gt; 0.05). The platelet count, PPR, and PSR were significantly different between the two groups [(145.92 ± 14.55) ×10<sup>9</sup>/L vs. (126.38 ± 23.85) ×10<sup>9</sup>/L, <italic>p</italic> = 0.008; 10.80 ± 1.30 vs. 9.01 ± 1.97, <italic>p</italic> = 0.004; 4.21 ± 0.65 vs. 3.33 ± 0.89, <italic>p</italic> = 0.02, respectively]. The PPR and PSR decreased gradually upon fibrosis aggravation (<italic>p</italic> &lt; 0.05). Based on the cut off value of the PPR (9.07) and PSR (3.54), their sensitivity and specificity was 0.917 and 0.525, and 0.833 and 0.541, respectively.</p></sec><sec><title>Conclusion</title><p>The PPR and PSR can be employed to assess earlier fibrosis progression among patients with HBV infection with HBeAg-negativity and a normal ALT level.</p></sec>