AUTHOR=Vinciguerra Riccardo , Herber Robert , Wang Yan , Zhang Fengju , Zhou Xingtao , Bai Ji , Yu Keming , Chen Shihao , Fang Xuejun , Raiskup Frederik , Vinciguerra Paolo 

TITLE=Corneal Biomechanics Differences Between Chinese and Caucasian Healthy Subjects

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.834663

DOI=10.3389/fmed.2022.834663

ISSN=2296-858X

ABSTRACT=<sec><title>Purpose</title><p>The aim of this study was to evaluate the difference between Caucasian and Chinese healthy subjects with regards to Corvis ST dynamic corneal response parameters (DCRs).</p></sec><sec><title>Methods</title><p>Two thousand eight hundred and eighty-nine healthy Caucasian and Chinese subjects were included in this multicenter retrospective study. Subsequently, Chinese eyes were matched to Caucasians by age, intraocular pressure (IOP), and Corneal Thickness (CCT) using a case-control matching algorithm. The DCRs assessed were Deformation Amplitude (DA) Applanation 1 velocity (A1v), integrated radius (1/R), deformation amplitude ratio (DAratio), stiffness parameter at applanation 1 (SPA1), ARTh (Ambrósio's Relational Thickness to the horizontal profile), and the novel Stress Strain Index (SSI).</p></sec><sec><title>Results</title><p>After age-, CCT-, and IOP- matching, 503 Chinese were assigned to 452 Caucasians participants. Statistical analysis showed a statistical significant difference between Chinese and Caucasian Healthy subjects in the values of SPA1 (<italic>p</italic> = 0.008), Arth (<italic>p</italic> = 0.008), and SSI (<italic>p</italic> &lt; 0.001). Conversely, DA, A1v, DAratio, and 1/R were not significantly different between the two ethnical groups (<italic>p</italic> &gt; 0.05).</p></sec><sec><title>Conclusion</title><p>We found significant differences in the values of the DCRs provided by the Corvis ST between Chinese and Caucasian healthy subjects.</p></sec>