AUTHOR=Ye Lingqing , Taylor Graham P. , Rosadas Carolina 

TITLE=Human T-Cell Lymphotropic Virus Type 1 and Strongyloides stercoralis Co-infection: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.832430

DOI=10.3389/fmed.2022.832430

ISSN=2296-858X

ABSTRACT=<sec><title>Background</title><p>The distribution of human T cell lymphotropic virus type 1 (HTLV-1) overlaps with that of <italic>Strongyloides stercoralis</italic>. <italic>Strongyloides stercoralis</italic> infection has been reported to be impacted by co-infection with HTLV-1. Disseminated strongyloidiasis and hyperinfection syndrome, which are commonly fatal, are observed in HTLV-1 co-infected patients. Reduced efficacy of anti-strongyloidiasis treatment in HTLV-1 carriers has been reported. The aim of this meta-analysis and systematic review is to better understand the association between HTLV-1 and <italic>S. stercoralis</italic> infection.</p></sec><sec><title>Methods</title><p>PubMed, Embase, MEDLINE, Global Health, Healthcare Management Information Consortium databases were searched. Studies regarding the prevalence of <italic>S. stercoralis</italic>, those evaluating the frequency of mild or severe strongyloidiasis, and treatment response in people living with and without HTLV-1 infection were included. Data were extracted and odds ratios were calculated. Random-effect meta-analysis was used to assess the pooled OR and 95% confidence intervals.</p></sec><sec><title>Results</title><p>Fourteen studies were included after full-text reviewing of which seven described the prevalence of <italic>S. stercoralis</italic> and HTLV-1. The odds of <italic>S. stercoralis</italic> infection were higher in HTLV-1 carriers when compared with HTLV-1 seronegative subjects (OR 3.2 95%CI 1.7–6.2). A strong association was found between severe strongyloidiasis and HTLV-1 infection (OR 59.9, 95%CI 18.1–198). Co-infection with HTLV-1 was associated with a higher rate of strongyloidiasis treatment failure (OR 5.05, 95%CI 2.5–10.1).</p></sec><sec><title>Conclusion</title><p><italic>Strongyloides stercoralis</italic> infection is more prevalent in people living with HTLV-1. Co-infected patients are more likely to develop severe presentation and to fail treatment. Screening for HTLV-1 and <italic>Strongyloides</italic> sp. should be routine when either is diagnosed.</p></sec>