AUTHOR=Yu Haozhe , Yuan Yifei , Wu Wenyu , Zeng Weizhen , Tong Louis , Zhang Yu , Feng Yun 

TITLE=Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.821106

DOI=10.3389/fmed.2022.821106

ISSN=2296-858X

ABSTRACT=<sec><title>Purpose</title><p>Previous studies suggest that overnight orthokeratology (OOK) may be detrimental to tear function. We aimed to investigate the effect of OOK on lipid layer thickness (LLT), blink pattern, and meibomian gland and elucidate the relationship of these variables.</p></sec><sec><title>Methods</title><p>Thirty-seven participants who wore OOK lenses every night for at least 2 years and twenty-four healthy non-contact lens wearers (controls) were enrolled in this retrospective study. LipiView interferometry, blink pattern analysis, the ocular surface status, and morphology and function of the meibomian gland were determined.</p></sec><sec><title>Results</title><p>The OOK group and healthy controls had similar LLT, blink patterns, ocular surface status, and the function of the meibomian gland. OOK participants demonstrated higher meiboscore in the lower eyelids (<italic>p</italic> &lt; 0.05) but not in the upper eyelids. Within the OOK group, LLT was significantly impacted by the partial blink rate (<italic>p</italic> &lt; 0.05) and the total score of the upper meibomian gland (<italic>p</italic> = 0.10).</p></sec><sec><title>Conclusions</title><p>Wearing OOK for 2 or more years increased lower eyelid meibomian gland dropout but did not have a reduction of LLT.</p></sec>