AUTHOR=Zhao Juemin , Dan Yanjun , Liu Ziqi , Wang Qianqian , Jiang Min , Zhang Chengfeng , Sheu Hamm-Ming , Lin Chrang-Shi , Xiang Leihong TITLE=Solamargine Alleviated UVB-Induced Inflammation and Melanogenesis in Human Keratinocytes and Melanocytes via the p38 MAPK Signaling Pathway, a Promising Agent for Post-inflammatory Hyperpigmentation JOURNAL=Frontiers in Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.812653 DOI=10.3389/fmed.2022.812653 ISSN=2296-858X ABSTRACT=
Post-inflammatory hyperpigmentation (PIH) is a common acquired pigmentary disorder occurring after skin inflammation or injury. Ultraviolet B irradiation could exaggerate PIH clinically due to its effect on promoting cutaneous inflammation and melanogenesis in keratinocytes and melanocytes, respectively. Solamargine (SM), a steroidal alkaloid glycoside extracted from