AUTHOR=Wei Yuanfeng , Gao Limin , Yang Xi , Xiang Xiaoyu , Yi Cheng TITLE=Inflammation-Related Genes Serve as Prognostic Biomarkers and Involve in Immunosuppressive Microenvironment to Promote Gastric Cancer Progression JOURNAL=Frontiers in Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.801647 DOI=10.3389/fmed.2022.801647 ISSN=2296-858X ABSTRACT=

Gastric cancer (GC) is a typical inflammatory-related malignant tumor which is closely related to helicobacter pylori infection. Tumor inflammatory microenvironment plays a crucial role in tumor progression and affect the clinical benefit from immunotherapy. In recent years, immunotherapy for gastric cancer has achieved promising outcomes, but not all patients can benefit from immunotherapy due to tumor heterogeneity. In our study, we identified 29 differentially expressed and prognostic inflammation-related genes in GC and normal samples. Based on those genes, we constructed a prognostic model using a least absolute shrinkage and selection operator (LASSO) algorithm, which categorized patients with GC into two groups. The high-risk group have the characteristics of “cold tumor” and have a poorer prognosis. In contrast, low-risk group was “hot tumor” and had better prognosis. Targeting inflammatory-related genes and remodeling tumor microenvironment to turn “cold tumor” into “hot tumor” may be a promising solution to improve the efficacy of immunotherapy for patients with GC.