AUTHOR=Gebetsberger Jennifer , Schirmer Michael , Wurzer Walter J. , Streif Werner 

TITLE=Low Bone Mineral Density in Hemophiliacs

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.794456

DOI=10.3389/fmed.2022.794456

ISSN=2296-858X

ABSTRACT=<sec><title>Objective</title><p>To review the current knowledge on bone health in patients with hemophilia A and the underlying pathogenetic mechanisms.</p></sec><sec><title>Data Sources</title><p>Original research articles, meta-analyses, and scientific reviews.</p></sec><sec><title>Data Synthesis</title><p>Already in childhood, patients with hemophilia A are prone to low bone mineral density, leading to osteopenia and/or osteoporosis. Initially associated with the life style of hemophilia, today we are faced with accumulating evidence that coagulation factor VIII is involved directly or indirectly in bone physiology.</p></sec><sec><title>Conclusion</title><p>Understanding the role of factor VIII and the mechanisms of decreased bone mineral density in hemophilia A is critically important, especially as non-factor replacement therapies are available, and treatment decisions potentially impact bone health.</p></sec>