AUTHOR=Pizevska Maja , Kaeda Jaspal , Fritsche Enrico , Elazaly Hisham , Reinke Petra , Amini Leila TITLE=Advanced Therapy Medicinal Products' Translation in Europe: A Developers' Perspective JOURNAL=Frontiers in Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.757647 DOI=10.3389/fmed.2022.757647 ISSN=2296-858X ABSTRACT=

Advanced Therapy Medicinal Products (ATMPs) comprising cell, gene, and tissue-engineered therapies have demonstrated enormous therapeutic benefits. However, their development is complex to be managed efficiently within currently existing regulatory frameworks. Legislation and regulation requirements for ATMPs must strike a balance between the patient safety while promoting innovations to optimize exploitation of these novel therapeutics. This paradox highlights the importance of on-going dynamic dialogue between all stakeholders and regulatory science to facilitate the development of pragmatic ATMP regulatory guidelines.