AUTHOR=Chopra Teena , Hecht Gail , Tillotson Glenn 

TITLE=Gut microbiota and microbiota-based therapies for Clostridioides difficile infection

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1093329

DOI=10.3389/fmed.2022.1093329

ISSN=2296-858X

ABSTRACT=<p><italic>Clostridioides difficile</italic> infection poses significant clinical challenges due to its recurrent nature. Current antibiotic management does not address the underlying issue, that of a disturbed gastrointestinal microbiome, called dysbiosis. This provides a supportive environment for the germination of <italic>C. difficile</italic> spores which lead to infection and toxin production as well as an array of other health conditions. The use of microbiome restoration therapies such as live biotherapeutics can reverse dysbiosis and lead to good clinical outcomes. Several such therapies are under clinical investigation.</p>