AUTHOR=Amrane Karim , Le Meur Coline , Thuillier Philippe , Alemany Pierre , Niel Clémence , Renault David , Abgral Ronan 

TITLE=Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on 18F-FDG-PET/CT

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1078560

DOI=10.3389/fmed.2022.1078560

ISSN=2296-858X

ABSTRACT=<p>Eosinophilic fasciitis (EF) is a rare connective tissue disorder causing inflammation and fibrosing of fascia. In this study, we present a very rare case of an immune checkpoint inhibitor (ICI)-induced EF revealed by <sup>18</sup>F-fluorodesoxyglucose positron emission tomography (FDG-PET/CT) 20 months after the initiation of Pembrolizumab treatment of a relapsed non-small cell lung cancer (NSCLC). This study presents a 52-year-old Caucasian woman clinically presenting asthenia, inflammatory muscle, and joint pain associated with subcutaneous nodules and symmetrical edema of the lower limbs. Iterative <sup>18</sup>FDG-PET/CT scans allow us to guide the therapeutic strategy due to this atypical ICI adverse event.</p>