AUTHOR=Baldi Federico , Dentone Chiara , Mikulska Malgorzata , Fenoglio Daniela , Mirabella Michele , Magnè Federica , Portunato Federica , Altosole Tiziana , Sepulcri Chiara , Giacobbe Daniele Roberto , Uras Chiara , Scavone Graziana , Taramasso Lucia , Orsi Andrea , Cittadini Giuseppe , Filaci Gilberto , Bassetti Matteo 

TITLE=Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2023

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1062450

DOI=10.3389/fmed.2022.1062450

ISSN=2296-858X

ABSTRACT=<p>COVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with the host immune system and the role of therapy still remains only partly understood. There are no data regarding the use of monoclonal antibodies and the combination of two antivirals in fighting viral replication and disease progression. We report the cases of two patients, both treated with rituximab for non-Hodgkin lymphoma and granulomatosis with polyangiitis, respectively, and both hospitalized for COVID-19 with positive SARS-CoV-2 RNAemia, who were successfully treated with a salvage combination therapy with sotrovimab, remdesivir and nirmatrelvir/ritonavir.</p>