AUTHOR=Wasnik Kirti , Mittal Pratima , Ghope Priti , Sonkar Subash C. , Arora Geetika , Saluja Daman 

TITLE=Multiple sexually transmitted co-infections are associated with adverse reproductive outcomes in asymptomatic adolescent pregnant women; A Prospective cohort study

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1046233

DOI=10.3389/fmed.2022.1046233

ISSN=2296-858X

ABSTRACT=<sec><title>Background</title><p>A prospective cohort was conducted to assess the prevalence of seven RTIs/STIs in adolescent asymptomatic pregnant women to find a significant correlation between infection and pregnancy.</p></sec><sec><title>Methods</title><p>The study was restricted to 18–19 years of asymptomatic adolescent pregnant women attending Ante-Natal Care and the health status of the pregnant women were followed up to parturition. The health status of the infant was followed till 6 months post-delivery. The prevalence of the concerning pathogens and the significance of their association with adverse outcomes of pregnancy were determined.</p></sec><sec><title>Results</title><p>Among 279 subjects, the most significant co-infections were observed for <italic>M. hominis with U. parvum</italic> (9.31%; <italic>p</italic>-value–0.0071/OR−2.6421<italic>)</italic> and <italic>U. urealyticum</italic> (7.88%; <italic>p</italic>-value–0.0119/OR−2.6455). Statistically significant associations were found between <italic>C. trachomatis</italic> [(<italic>p</italic>-value-0.0439); OR−2.9902] and <italic>M. genitalium</italic> [(<italic>p</italic>-value−0.0284); OR−3.442] with PTB<italic>, N. gonorrhoeae</italic> with LBW &lt;2.5 kg [(<italic>p</italic>-value−0.0052);OR−4.9017]<italic>, U. urealyticum</italic> with VLBW &lt;2 kg [(<italic>p</italic>-value-0.0262);OR−3.0207]<italic>, M. genitalium</italic> [(<italic>p</italic>-value-0.0184); OR−11.7976] <italic>and T. vaginalis with</italic> PROM [(<italic>p</italic>-value 0.0063); OR−19.4275] <italic>while M. genitalium</italic> [(<italic>p</italic>-value 0.0190); OR<bold>–</bold>12.9230] <italic>and U. urealyticum</italic> [(<italic>p</italic>-value 0.0063); OR<bold>-</bold>14.5149] <italic>with</italic> PPROM with 95% CI respectively.</p></sec><sec><title>Conclusions</title><p>Asymptomatic adolescents are at high risk of adverse pregnancy outcomes if infected with the concerned pathogens.</p></sec>