AUTHOR=Wang Dong , Wang Jingyi , Zheng Xi , Diao Shuo , Li Wenxiong , Ma Wenliang 

TITLE=Bone homeostasis disorders increased the mortality of sepsis patients: A preliminary retrospective cohort study

JOURNAL=Frontiers in Medicine

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1017411

DOI=10.3389/fmed.2022.1017411

ISSN=2296-858X

ABSTRACT=<sec><title>Introduction</title><p>Sepsis is a common clinical syndrome and nearly 20% of all deaths are related to sepsis. As an important part of the body, bone homeostasis disorders are closely related to inflammatory response, but the correlation between bone homeostasis and sepsis, sepsis shock was unknown. The objective of this study was to explore the relation of bone homeostasis on sepsis and sepsis shock.</p></sec><sec><title>Methods</title><p>In this retrospective cohort study, patients were enrolled between April 2018 and May 2022 from Beijing Chaoyang hospital. Primary outcomes were serum indicators reflected bone homeostasis, such as cross-linked carboxy-terminal telopeptide of type I collagen (CTX-I), tartrate-resistant acid phosphatase 5b (TRACP-5b) and piezo-type mechanosensitive ion channel component 1 (PIEZO1).</p></sec><sec><title>Results</title><p>The data were analyzed retrospectively. among 88 evaluable patients, 45 were sepsis (19 were sepsis shock) and 43 were non-sepsis. There was no significant difference in age, gender, BMI, combination diseases, operation time, intraoperative blood loss, and hospital stay. Patients with sepsis or sepsis shock had higher serum CTX-I, TRACP-5b, PIEZO1 (<italic>p</italic> &lt; 0.05). Spearman’s rank correlation test showed that CTX-I, TRACP-5b, PIEZO1 and the three together (CTX-I + TRACP-5b + PIEZO1) had strong correlation with sepsis or sepsis shock (<italic>p</italic> &lt; 0.05). The receiver operating characteristic curve (ROC) and precision-recall curve (PRC) showed that these indicators could predict the occurrence of sepsis or sepsis shock (<italic>p</italic> &lt; 0.05). Besides, decision curve analysis (DCA) and interventions avoided curve (IAC) displayed a high net benefit of bone homeostasis disorders indicators on sepsis or sepsis shock. Kaplan–Meier survival curves revealed that sepsis or shock patients with high value indicators (&gt;0.47227) had a higher mortality (<italic>p</italic> &lt; 0.05).</p></sec><sec><title>Conclusion</title><p>Bone homeostasis disorders could increase the mortality of sepsis and sepsis shock patients.</p></sec>