AUTHOR=Catalano Martina , Roviello Giandomenico , Galli Ilaria Camilla , Santi Raffaella , Nesi Gabriella TITLE=Immune checkpoint inhibitor induced nephrotoxicity: An ongoing challenge JOURNAL=Frontiers in Medicine VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1014257 DOI=10.3389/fmed.2022.1014257 ISSN=2296-858X ABSTRACT=

Although immune checkpoint inhibitors (ICIs) have dramatically revolutionized the field of oncology over the last decade, severe immune-related adverse events (irAEs) are potentially life-threatening. In comparison with toxicities involving the skin, gastrointestinal tract and endocrine system, nephrotoxicity is less common but often underestimated due to difficult diagnosis. Management usually consists of treatment discontinuation and/or corticosteroid use. In this review, we summarize current knowledge of ICI-induced nephrotoxicity, evaluating drawbacks and future perspectives.