AUTHOR=Moeller Marcus J. , Kramann Rafael , Lammers Twan , Hoppe Bernd , Latz Eicke , Ludwig-Portugall Isis , Boor Peter , Floege Jürgen , Kurts Christian , Weiskirchen Ralf , Ostendorf Tammo 

TITLE=New Aspects of Kidney Fibrosis–From Mechanisms of Injury to Modulation of Disease

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.814497

DOI=10.3389/fmed.2021.814497

ISSN=2296-858X

ABSTRACT=<p>Organ fibrogenesis is characterized by a common pathophysiological final pathway independent of the underlying progressive disease of the respective organ. This makes it particularly suitable as a therapeutic target. The Transregional Collaborative Research Center “Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease” (referred to as SFB/TRR57) was hosted from 2009 to 2021 by the Medical Faculties of RWTH Aachen University and the University of Bonn. This consortium had the ultimate goal of discovering new common but also different fibrosis pathways in the liver and kidneys. It finally successfully identified new mechanisms and established novel therapeutic approaches to interfere with hepatic and renal fibrosis. This review covers the consortium's key kidney-related findings, where three overarching questions were addressed: (i) What are new relevant mechanisms and signaling pathways triggering renal fibrosis? (ii) What are new immunological mechanisms, cells and molecules that contribute to renal fibrosis?, and finally (iii) How can renal fibrosis be modulated?</p>