AUTHOR=Liu Jiaxi , Gao Jinfang , Wu Zewen , Mi Liangyu , Li Na , Wang Yajing , Peng Xinyue , Xu Ke , Wu Fengping , Zhang Liyun 

TITLE=Anti-citrullinated Protein Antibody Generation, Pathogenesis, Clinical Application, and Prospects

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.802934

DOI=10.3389/fmed.2021.802934

ISSN=2296-858X

ABSTRACT=<p>Anti-citrullinated protein antibodies (ACPAs) are autoantibodies commonly observed in patients with rheumatoid arthritis (RA). Currently, most of the mechanisms of ACPA formation and bone destruction are well-understood, however, some unknown mechanisms still exist. There have been many new advances in ACPA-related clinical applications and targeted therapies. However, the existence of different ACPA subtypes is a limitation of targeted therapy. Herein, we present an overview of the process of ACPA generation, the underlying pathogenesis, and relevant clinical application and prospects.</p>