AUTHOR=Liu Rongqiang , Li Rongqi , Yu Haoyuan , Liu Jianrong , Zheng Shiyang , Li Yang , Ye Linsen 

TITLE=NTF3 Correlates With Prognosis and Immune Infiltration in Hepatocellular Carcinoma

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.795849

DOI=10.3389/fmed.2021.795849

ISSN=2296-858X

ABSTRACT=<p><bold>Background:</bold> The potential role of Neurotrophic factor-3(NTF3) in liver cancer is unknown. Therefore, we aimed to explore the clinical value of NTF3 in hepatocellular carcinoma (HCC).</p><p><bold>Methods:</bold> We used a variety of databases to analyze the expression, relationship with prognosis and immune significance of NTF3 in liver cancer through bioinformatics.</p><p><bold>Results:</bold> NTF3 was low expressed in HCC and was an independent prognostic factor in patients with HCC. CIBERSORT analysis indicated that NTF3 expression was positively correlated with CD4+ cells, mast cells, NK cells, macrophages and B cells in the tumor microenvironment. Furthermore, we found that NTF3 expression was negatively correlated with the immune checkpoints PD-L1, TIGIT and TIM-3. Functional network analysis revealed that NTF3 regulates HCC progression through a variety of cancer-related kinases, transcription factors and signaling pathways.</p><p><bold>Conclusions:</bold> We demonstrate that NTF3 correlates with prognosis and immune infiltration in HCC.</p>