AUTHOR=Nguyen Thi H. O. , Cohen Carolyn A. , Rowntree Louise C. , Bull Maireid B. , Hachim Asmaa , Kedzierska Katherine , Valkenburg Sophie A. 

TITLE=T Cells Targeting SARS-CoV-2: By Infection, Vaccination, and Against Future Variants

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.793102

DOI=10.3389/fmed.2021.793102

ISSN=2296-858X

ABSTRACT=<p>T cell responses are a key cornerstone to viral immunity to drive high-quality antibody responses, establishing memory for recall and for viral clearance. Inefficient recruitment of T cell responses plays a role in the development of severe COVID-19 and is also represented by reduced cellular responses in men, children, and diversity compared with other epitope-specific subsets and available T cell receptor diversity. SARS-CoV-2-specific T cell responses are elicited by multiple vaccine formats and augmented by prior infection for hybrid immunity. Epitope conservation is relatively well-maintained leading to T cell crossreactivity for variants of concern that have diminished serological responses.</p>