AUTHOR=Chen Chen , Lou Ning , Zheng Xin , Wang Shasha , Chen Haizhu , Han Xiaohong 

TITLE=Trends of Phase I Clinical Trials of New Drugs in Mainland China Over the Past 10 Years (2011–2020)

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.777698

DOI=10.3389/fmed.2021.777698

ISSN=2296-858X

ABSTRACT=<p><bold>Background:</bold> In recent years, the number of clinical trials initiated in China has increased rapidly. The aim of this study was to overview the changing landscape of phase I clinical trials in mainland China from 2011 to 2020.</p><p><bold>Methods:</bold> We analyzed phase I clinical trials registered on 3 websites including the Chinese Clinical Trial Registry, <ext-link ext-link-type="uri" xlink:href="https://ClinicalTrials.gov" xmlns:xlink="http://www.w3.org/1999/xlink">ClinicalTrials.gov</ext-link>, and the China National Medical Products Administration Center for Drug Evaluation platform.</p><p><bold>Findings:</bold> A total of 2,842 phase I clinical trials were posted from January 1, 2011, to December 31, 2020. The overall number of clinical trials for innovative drugs was 1,497, accounting for half of all the phase I clinical trials (53%). Among these 1,486 innovative drug clinical trials, 924 were newly tested drugs with an average annual growth rate of 59%. Biological drug research increased significantly from 22.6% during 2011–2015 to 33.3% during 2016–2020. These principal investigators (PIs) of these clinical trials were mainly from Beijing (<italic>n</italic> = 871), followed by Shanghai (<italic>n</italic> = 496) and Jiangsu (<italic>n</italic> = 281). As for the therapeutic area of phase I clinical trials, cancer took up the most percentage of all the clinical trials (35%), followed by infectious disease (9%), nervous system disease (9%), etc. Most phase I clinical trials are conducted on healthy volunteers (<italic>n</italic> = 1,642, 57.8%), some cancer drugs are conducted in patients with cancer (<italic>n</italic> = 846, 29.8%), and only a few clinical trials were conducted in the elderly (<italic>n</italic> = 7). Among these clinical trials of the newly tested innovative drugs, the first in human (FIH) clinical trials accounted for 82% (744), and the First in Chinese (FIC) clinical trials only took up 18% (167). Only a small number of drugs could be made the transition to phase II (<italic>n</italic> = 207, 22%). In addition, despite the number of newly tested drugs during 2011–2015 (<italic>n</italic> = 163) was much less than that in 2016–2020 (<italic>n</italic> = 761), the percentage of drugs that could enter into phase II clinical trials in 2011–2015 (34%) was higher than that in 2016–2020 (20%).</p><p><bold>Conclusion:</bold> In the past 10 years, the development of phase I clinical trials has achieved great progress in mainland China due to the novel design and drug innovation policy. Nevertheless, future efforts are needed to make for improving the phase transition success rate of innovative drugs.</p>