AUTHOR=Fang Shanyu , Zhang Ping , Chen Xinping , Liu Fujun , Wang Fen 

TITLE=Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.776876

DOI=10.3389/fmed.2021.776876

ISSN=2296-858X

ABSTRACT=<p>Our previous study manifested that lanthanum chloride (LaCl<sub>3</sub>) can enhance the anticancer ability of cisplatin (DDP) in ovarian cancer cells. Here, ovarian cancer cells SKOV3 and SKOV3/DDP were subjected to DDP and LaCl<sub>3</sub>. Cell viability, apoptosis, DNA repair, and PI3K/Akt pathway were detected. LaCl<sub>3</sub> induced more cell death and apoptosis caused by DDP in two cell lines, accompanied by upregulation of Bax and Cleaved caspase 3 proteins, and downregulation of Bcl-2 protein. LaCl<sub>3</sub> also could decrease RAD51 protein by inactivation of the PI3K/Akt pathway. These data indicated that LaCl<sub>3</sub> could be a potential drug to modulate DDP resistance by inactivating of PI3K/Akt pathway and attenuating DNA repair in ovarian cancer.</p>