AUTHOR=Croitoru Vlad M. , Cazacu Irina M. , Popescu Ionut , Paul Doru , Dima Simona Olimpia , Croitoru Adina Emilia , Tanase Alina Daniela 

TITLE=Clonal Hematopoiesis and Liquid Biopsy in Gastrointestinal Cancers

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.772166

DOI=10.3389/fmed.2021.772166

ISSN=2296-858X

ABSTRACT=<p>The use of blood liquid biopsy is increasingly being incorporated into the clinical setting of gastrointestinal cancers care. Clonal hematopoiesis (CH) occurs naturally as a result of the accumulation of somatic mutations and the clonal proliferation of hematopoietic stem cells with normal aging. The identification of CH-mutations has been described as a source of biological noise in blood liquid biopsy. Incorrect interpretation of CH events as cancer related can have a direct impact on cancer diagnosis and treatment. This review summarizes the current understanding of CH as a form of biological noise in blood liquid biopsy and the reported clinical significance of CH in patients with GI cancers.</p>