AUTHOR=Wu Jing , Li Xin-Yue , Fang Xia , Teng Fang-Yuan , Xu Yong 

TITLE=Decreased Serum Maresin 1 Concentration Is Associated With Postmenopausal Osteoporosis: A Cross-Sectional Study

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.759825

DOI=10.3389/fmed.2021.759825

ISSN=2296-858X

ABSTRACT=<p><bold>Background:</bold> Maresin 1 plays a role in the regulation of inflammation and metabolic diseases <italic>in vivo</italic>. An increasing number of studies have reported that postmenopausal osteoporosis (PMOP) is associated with inflammation. However, the potential relationship between the serum Maresin 1 content and PMOP is unclear.</p><p><bold>Aims:</bold> 1) To evaluate the Maresin 1 content in postmenopausal women with osteopenia, osteoporosis, or without these conditions (normal group) and 2) to analyze the correlations between Maresin 1 concentrations and bone mineral density (BMD) and bone turnover markers.</p><p><bold>Methods:</bold> In this cross-sectional study, we measured serum Maresin 1 concentrations, serum biochemical parameters, markers of bone metabolism, and BMD of the femoral neck, lumbar spine, and hip in 141 postmenopausal women.</p><p><bold>Results:</bold> We found that serum Maresin 1 in the osteopenia (140.09 ± 30.54 pg/ml) and PMOP (124.68 ± 31.35 pg/ml) groups were significantly lower than those in the normal group (167.38 ± 24.85 pg/ml) (<italic>P</italic> &lt; 0.05 and <italic>P</italic> &lt; 0.001). Serum Maresin 1 levels were positively correlated with femoral neck, lumbar spine, and hip BMD (<italic>P</italic> &lt; 0.001). Meanwhile, Maresin 1 concentrations were positively associated with 25-hydroxyvitamin D [25(OH)D] levels (<italic>P</italic> &lt; 0.001), but negatively correlated with β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide (β-CTX) (<italic>P</italic> = 0.002), procollagen type I amino-terminal propeptide (PINP) (<italic>P</italic> = 0.004), tartrate-resistant acid phosphatase 5b (TRAP-5b) (<italic>P</italic> = 0.005), and osteocalcin (OC) levels (<italic>P</italic> = 0.001). Multivariate logistic regression analysis showed that a decrease in Maresin 1 concentration was still associated with osteopenia (<italic>P</italic> = 0.035) or PMOP (<italic>P</italic> = 0.016). Maresin 1 levels had a maximum area under curve of 0.820 for osteopenia and 0.746 for PMOP (<italic>P</italic> &lt; 0.001). Our results showed that the serum Maresin 1 levels were reduced in osteopenia and PMOP patients compared with that in normal subjects, and were the lowest in the PMOP subjects. The results suggest that Maresin 1 may serve as a new non-invasive diagnostic biomarker for PMOP.</p>