AUTHOR=Agarwal Aniruddha , Handa Sabia , Marchese Alessandro , Parrulli Salvatore , Invernizzi Alessandro , Erckens Roel J. , Berendschot Tos T. J. M. , Webers C. A. B. , Bansal Reema , Gupta Vishali 

TITLE=Optical Coherence Tomography Findings of Underlying Choroidal Neovascularization in Punctate Inner Choroidopathy

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.758370

DOI=10.3389/fmed.2021.758370

ISSN=2296-858X

ABSTRACT=<p><bold>Purpose:</bold> To analyze findings on optical coherence tomography (OCT) suggestive of choroidal neovascularization (CNV) in lesions of punctate inner choroidopathy (PIC).</p><p><bold>Methods:</bold> In this multi-center retrospective study, clinical data of patients with PIC were retrospectively analyzed. Quantitative data (height, width, and volume of PIC lesions), and qualitative data (disruption of ellipsoid zone (EZ)/Bruch's membrane (BM), outer retinal fuzziness, and choroidal back-shadowing) were compared between CNV+ and CNV– groups using Mann–Whitney <italic>U</italic>-test and Fischer's exact test.</p><p><bold>Results:</bold> In total, 35 eyes (29 patients; 21 women; mean age: 33.3 ± 6.5 years) were selected for analysis. Of the 35 PIC lesions studied, 17 had underlying CNV. Lesions with CNV+ had larger height, width, and volume (<italic>p</italic> &lt; 0.001) and several distinctive features, such as disruption of EZ and BM, outer retinal fuzziness, and hypo-reflective back-shadowing (<italic>p</italic> &lt; 0.001) compared with CNV—lesions.</p><p><bold>Conclusions:</bold> Quantitative and qualitative OCT analysis can aid in the prediction of an underlying CNV in the eyes with PIC.</p>