AUTHOR=Wu Qiaowei , Hu Yijun , Liu Baoyi , Lin Zhanjie , Xiao Yu , Zeng Xiaomin , Fang Ying , Yan Ying , Ye Ya , Yan Ming , Huang Zhen , Yu Honghua , Song Yanping , Zang Siwen 

TITLE=Factors Associated With the Presence of Foveal Bulge in Eyes With Resolved Diabetic Macular Edema

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.755609

DOI=10.3389/fmed.2021.755609

ISSN=2296-858X

ABSTRACT=<p><bold>Purpose:</bold> To evaluate factors associated with the presence of foveal bulge (FB) in resolved diabetic macular edema (DME) eyes.</p><p><bold>Methods:</bold> A total of 165 eyes with complete integrity of ellipsoid zone (EZ) at the fovea and resolved DME were divided into two groups according to the presence of FB at 6 months after intravitreal injection of ranibizumab treatment. Best-corrected visual acuity (BCVA), central foveal thickness (CFT), outer nuclear layer (ONL) thickness, height of serous retinal detachment (SRD) and non-SRD, and inner segment (IS) and outer segment (OS) lengths of the two groups were measured and compared at baseline and each follow-up. The correlations between the presence of FB and pre- and post-treatment factors were determined by logistic regression analysis.</p><p><bold>Results:</bold> At baseline, BCVA was significantly better, and CFT and incidence and height of SRD were significantly lower in the FB (+) group (all <italic>P</italic> &lt; 0.05). At 6 months, FB was present in 65 (39.39%) eyes. Post-treatment BCVA was significantly better and OS length was significantly longer in the FB (+) group at 6 months (all <italic>P</italic> &lt; 0.05). Multivariate analysis identified younger age, better BCVA, and lower CFT before treatment as significant predictors of the existence of FB at 6 months (all <italic>P</italic> &lt; 0.05). At 6 months, better BCVA and longer OS length were significantly correlated with the existence of FB (all <italic>P</italic> &lt; 0.05).</p><p><bold>Conclusions:</bold> Factors associated with the presence of FB after the resolution of DME include younger age, better baseline BCVA and lower baseline CFT, and better post-treatment BCVA and longer post-treatment OS length.</p>