AUTHOR=Zhang Yu-han , Hu Xiao-fei , Ma Jie-chao , Wang Xian-qi , Luo Hao-ran , Wu Zi-feng , Zhang Shu , Shi De-jun , Yu Yi-zhou , Qiu Xiao-ming , Zeng Wen-bing , Chen Wei , Wang Jian 

TITLE=Clinical Applicable AI System Based on Deep Learning Algorithm for Differentiation of Pulmonary Infectious Disease

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.753055

DOI=10.3389/fmed.2021.753055

ISSN=2296-858X

ABSTRACT=<p><bold>Objective:</bold> To assess the performance of a novel deep learning (DL)-based artificial intelligence (AI) system in classifying computed tomography (CT) scans of pneumonia patients into different groups, as well as to present an effective clinically relevant machine learning (ML) system based on medical image identification and clinical feature interpretation to assist radiologists in triage and diagnosis.</p><p><bold>Methods:</bold> The 3,463 CT images of pneumonia used in this multi-center retrospective study were divided into four categories: bacterial pneumonia (<italic>n</italic> = 507), fungal pneumonia (<italic>n</italic> = 126), common viral pneumonia (<italic>n</italic> = 777), and COVID-19 (<italic>n</italic> = 2,053). We used DL methods based on images to distinguish pulmonary infections. A machine learning (ML) model for risk interpretation was developed using key imaging (learned from the DL methods) and clinical features. The algorithms were evaluated using the areas under the receiver operating characteristic curves (AUCs).</p><p><bold>Results:</bold> The median AUC of DL models for differentiating pulmonary infection was 99.5% (COVID-19), 98.6% (viral pneumonia), 98.4% (bacterial pneumonia), 99.1% (fungal pneumonia), respectively. By combining chest CT results and clinical symptoms, the ML model performed well, with an AUC of 99.7% for SARS-CoV-2, 99.4% for common virus, 98.9% for bacteria, and 99.6% for fungus. Regarding clinical features interpreting, the model revealed distinctive CT characteristics associated with specific pneumonia: in COVID-19, ground-glass opacity (GGO) [92.5%; odds ratio (OR), 1.76; 95% confidence interval (CI): 1.71–1.86]; larger lesions in the right upper lung (75.0%; OR, 1.12; 95% CI: 1.03–1.25) with viral pneumonia; older age (57.0 years ± 14.2, OR, 1.84; 95% CI: 1.73–1.99) with bacterial pneumonia; and consolidation (95.8%, OR, 1.29; 95% CI: 1.05–1.40) with fungal pneumonia.</p><p><bold>Conclusion:</bold> For classifying common types of pneumonia and assessing the influential factors for triage, our AI system has shown promising results. Our ultimate goal is to assist clinicians in making quick and accurate diagnoses, resulting in the potential for early therapeutic intervention.</p>