AUTHOR=Huang Peng , Hou Yu-Qing , Wu Jing-Jing , Wang Yi-Di , Ye Xiang-Yu , Zang Feng , Yu Rong-Bin , Yang Sheng 

TITLE=Genetic Mutations in TNFSF11 Were Associated With the Chronicity of Hepatitis C Among Chinese Han Population

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.743406

DOI=10.3389/fmed.2021.743406

ISSN=2296-858X

ABSTRACT=<p><bold>Background:</bold> Recently, several studies have reported that the host immune response can be related to the RANKL/RANK/OPG signaling pathway. However, the associations of <italic>TNFSF11, TNFRSF11A</italic>, and <italic>TNFRSF11B</italic> gene polymorphisms in the RANKL/RANK/OPG pathway with hepatitis C virus (HCV) infection outcomes remain unclear.</p><p><bold>Methods:</bold> In this case-control study, 768 persistent HCV infection and 503 spontaneous HCV clearance cases, and 1,259 control subjects were included. The Taman-MGB probe method was utilized to detect <italic>TNFSF11</italic> rs9525641, <italic>TNFRSF11A</italic> rs8686340, and <italic>TNFRSF11B</italic> rs2073618 genotypes. The distribution of three single nucleotide polymorphisms (SNPs) genotypes was analyzed using stata14.0.</p><p><bold>Results:</bold> SNPs rs9525641, rs8086340, and rs2073618 genotype frequencies followed the Hardy-Weinberg natural population equilibrium (<italic>p</italic> = 0.637, 0.250, and 0.113, respectively). Also, rs9525641 was significantly associated with HCV chronicity risk in recessive (OR = 1.203, 95% CI: 1.018–1.420, <italic>p</italic> = 0.030) and additive models (OR = 1.545, 95% CI: 1.150–2.075, <italic>p</italic> = 0.004). The stratified analysis showed that rs9525641 variant genotypes were associated with HCV chronicity among people older than 50 years (OR =1.562, 95% CI: 1.079–2.262, <italic>p</italic> = 0.018), females (OR = 1.667, 95% CI: 1.145–2.429, <italic>p</italic> = 0.008), ALT &lt;40 U/L (OR = 1.532, 95% CI: 1.074–2.286, <italic>p</italic> = 0.018), and AST &lt; 40 U/L (OR = 1.552, 95% CI: 1.095–2.201, <italic>p</italic> = 0.014).</p><p><bold>Conclusion:</bold><italic>TNFRSF11</italic> rs9525641 was significantly associated with HCV chronicity in the Chinese population.</p>