AUTHOR=Cai Wang-Yu , Luo Xi , Song Jianyuan , Ji Danpin , Zhu Jun , Duan Cuicui , Wu Wei , Wu Xiao-Ke , Xu Jian 

TITLE=Effect of Hyperinsulinemia and Insulin Resistance on Endocrine, Metabolic, and Reproductive Outcomes in Non-PCOS Women Undergoing Assisted Reproduction: A Retrospective Cohort Study

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2022

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.736320

DOI=10.3389/fmed.2021.736320

ISSN=2296-858X

ABSTRACT=<p><bold>Objective:</bold> To evaluate the effect of hyperinsulinemia (HI) and insulin resistance (IR) on endocrine, metabolic, and reproductive outcomes in women without polycystic ovary syndrome (PCOS) undergoing assisted reproduction.</p><p><bold>Materials and Methods:</bold> The study included 1,104 non-PCOS women undergoing <italic>in vitro</italic> fertilization/intracytoplasmic sperm injection-fresh embryo transfer. HI was evaluated by serum fasting insulin (FIN), and IR was evaluated by homeostatic model assessment of insulin resistance index (HOMA-IR). In addition, biometric, sex hormone, and metabolic parameters were measured. Independent <italic>t</italic>-test, linear, and logistic regression examined associations between HI, IR, and endocrine, metabolic, ovarian stimulation characteristics, and reproductive outcomes.</p><p><bold>Results:</bold> Women with HI and IR had lower levels of progesterone, luteinizing hormone, follicle-stimulating hormone, estradiol, high-density lipoproteins, and increased levels of triglycerides low-density lipoproteins. For ovarian stimulation characteristics, those with HI and IR had a longer duration of stimulation, a higher total gonadotropin dose, and a lower peak estradiol level. Linear regression confirmed these associations. For reproductive outcomes, HI and IR were not associated with clinical pregnancy, live birth, and miscarriage.</p><p><bold>Conclusions:</bold> HI and IR did not impair reproductive outcomes in non-PCOS women undergoing assisted reproduction.</p>