AUTHOR=Liu Jing-Hua , Deng Guangda , Ma Jing , Li Liang , Fang Yuxin , Li Songfeng , Lu Hai 

TITLE=Clinical Characteristics of Pediatric Coats' Disease With Retinal Cyst Using Wide-Angle Fluorescein Angiography

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.709522

DOI=10.3389/fmed.2021.709522

ISSN=2296-858X

ABSTRACT=<p><bold>Purpose:</bold> To assess the demographic and treatment features of pediatric patients of Coats' disease with retinal cyst using wide-angle FA.</p><p><bold>Design:</bold> A retrospective, hospital based, cross-sectional study.</p><p><bold>Participants:</bold> Pediatric patients of Coats' disease underwent wide-angle FA.</p><p><bold>Methods:</bold> A retrospective review of pediatric patients of Coats' disease who underwent wide-angle FA at a single center from January 2015 to July 2020. Demographic and treatment features were compared between patients with or without retinal cyst.</p><p><bold>Main Outcome Measures:</bold> Demographic and treatment outcomes.</p><p><bold>Results:</bold> There were 123 pediatric Coats' patients in our study, and 18.70% (23/123) of the patients developed complications with retinal cyst, 73.9% (17/23) of the retinal cysts were located in the inferior-temporal quadrant and 82.6% (19/23) of the retinal cysts were located in the peripheral retina anterior to the vortex veins. Compared with patients without retinal cyst, patients with retinal cyst had more clock-hours of telangiectasia on FA (7.32 vs. 5.41, <italic>p</italic> = 0.031), and may need more total treatments (7.47 vs. 3.53, <italic>p</italic> = 0.023) including laser photocoagulation (4.08 vs. 2.31, <italic>p</italic> = 0.019) or intravitreal anti-VEGF (3.13 vs. 2.23, <italic>p</italic> = 0.039), and also required a longer time for telangiectasia resolution (22.33 vs. 18.53 months, <italic>p</italic> = 0.043).</p><p><bold>Conclusion:</bold> Pediatric patients with Coats' disease complicated by retinal cyst presented with more clock-hours of telangiectasia on FA and needed more total treatments and longer time for telangiectasia resolution.</p>