AUTHOR=Liu Xiaozhu , Yue Song , Huang Haodong , Duan Minjie , Zhao Binyi , Liu Jin , Xiang Tianyu 

TITLE=Risk Stratification Model for Predicting the Overall Survival of Elderly Triple-Negative Breast Cancer Patients: A Population-Based Study

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.705515

DOI=10.3389/fmed.2021.705515

ISSN=2296-858X

ABSTRACT=<p><bold>Background:</bold> The objective of this study was to evaluate the prognostic value of clinical characteristics in elderly patients with triple-negative breast cancer (TNBC).</p><p><bold>Methods:</bold> The cohort was selected from the Surveillance, Epidemiology, and End Results (SEER) program dating from 2010 to 2015. Univariate and multivariate analyses were performed using a Cox proportional risk regression model, and a nomogram was constructed to predict the 1-, 3-, and 5-year prognoses of elderly patients with TNBC. A concordance index (C-index), calibration curve, and decision curve analysis (DCA) were used to verify the nomogram.</p><p><bold>Results:</bold> The results of the study identified a total of 5,677 patients who were randomly divided 6:4 into a training set (<italic>n</italic> = 3,422) and a validation set (<italic>n</italic> = 2,255). The multivariate analysis showed that age, race, grade, TN stage, chemotherapy status, radiotherapy status, and tumor size at diagnosis were independent factors affecting the prognosis of elderly patients with TNBC. Together, the 1 -, 3 -, and 5-year nomograms were made up of 8 variables. For the verification of these results, the C-index of the training set and validation set were 0.757 (95% CI 0.743–0.772) and 0.750 (95% CI 0.742–0.768), respectively. The calibration curve also showed that the actual observation of overall survival (OS) was in good agreement with the prediction of the nomograms. Additionally, the DCA showed that the nomogram had good clinical application value. According to the score of each patient, the risk stratification system of elderly patients with TNBC was further established by perfectly dividing these patients into three groups, namely, low risk, medium risk, and high risk, in all queues. In addition, the results showed that radiotherapy could improve prognosis in the low-risk group (<italic>P</italic> = 0.00056), but had no significant effect in the medium-risk (<italic>P</italic> &lt; 0.4) and high-risk groups (<italic>P</italic> &lt; 0.71). An online web app was built based on the proposed nomogram for convenient clinical use.</p><p><bold>Conclusion:</bold> This study was the first to construct a nomogram and risk stratification system for elderly patients with TNBC. The well-established nomogram and the important findings from our study could guide follow-up management strategies for elderly patients with TNBC and help clinicians improve individual treatment.</p>