AUTHOR=Mohamed-Noriega Karim , Treviño-Herrera Alan B. , Mohamed-Noriega Jibran , Velasco-Sepúlveda Braulio H. , Martínez-Pacheco Víctor A. , Guevara-Villarreal Dante A. , Rodríguez-Medellín Delia L. , Sepúlveda-Salinas Anna G. , Villarreal-Méndez Gerardo , González-Cortés Jesús H. , Elizondo-Omaña Rodrigo E. , Guzmán-López Santos , Mohamed-Hamsho Jesús 

TITLE=Relationship of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio With Visual Acuity After Surgical Repair of Open Globe Injury

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.697585

DOI=10.3389/fmed.2021.697585

ISSN=2296-858X

ABSTRACT=<p><bold>Purpose:</bold> To assess the relationship and prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with poor final best-corrected visual acuity (BCVA) after surgical repair of open globe injuries (OGI) in adults.</p><p><bold>Design:</bold> Retrospective analysis of data from an ongoing prospective cohort of consecutive patients.</p><p><bold>Methods:</bold> In a tertiary university hospital, 197 eyes of 197 patients were included between 2013 and 2017. NLR and PLR were obtained from pre-operative blood tests to analyze its relationship with poor final BCVA.</p><p><bold>Results:</bold> Severe visual impairment (SVI) was defined as ≤20/200, and was observed in 96 (48.7%) patients after surgical repair of OGI. SVI patients had higher NLR (7.4 ± 6.6 vs. 4.0 ± 3.2, <italic>p</italic> &lt; 0.001), and PLR (167 ± 92 vs. 139 ± 64; <italic>p</italic> = 0.021) than non-SVI. NLR ≥ 3.47 and PLR ≥ 112.2 were the best cut-off values for SVI, were univariate risk factors for SVI, and had sensitivity: 69.0, 71.4, and specificity: 63.6, 44.8, respectively. In multivariate analysis, only OTS, athalamia, and hyphema remained as risk factors. NLR had significant correlation with ocular trauma score (OTS) (<italic>r</italic> = −0.389, <italic>p</italic> &lt; 0.001) and final BCVA (<italic>r</italic> = 0.345, <italic>p</italic> &lt; 0.001).</p><p><bold>Limitations:</bold> Simultaneous trauma in other parts of the body that could influence the laboratory findings.</p><p><bold>Conclusion:</bold> Patients with SVI after a repaired OGI had increased pre-operative NLR and PLR levels. High NLR and PLR are risk factors for SVI in univariate analysis. It is confirmed that low OTS is a risk factor for SVI. High NLR and PLR could be used as a prognostic tool to identify patients at higher risk for SVI after repair of OGI.</p>