AUTHOR=Marinho Penélope Saldanha , da Cunha Antonio José Ledo Alves , Chimelli Leila , Avvad-Portari Elyzabeth , Andreiuolo Felipe da Matta , de Oliveira-Szejnfeld Patrícia Soares , Mendes Mayara Abud , Gomes Ismael Carlos , Souza Letícia Rocha Q. , Guimarães Marilia Zaluar , Goldman Suzan Menasce , de Oliveira Mariana Barros Genuíno , Rehen Stevens , Amim Joffre , Tovar-Moll Fernanda , Prata-Barbosa Arnaldo 

TITLE=Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.677001

DOI=10.3389/fmed.2021.677001

ISSN=2296-858X

ABSTRACT=<p>SARS-CoV-2 infection during pregnancy is not usually associated with significant adverse effects. However, in this study, we report a fetal death associated with mild COVID-19 in a 34-week-pregnant woman. The virus was detected in the placenta and in an unprecedented way in several fetal tissues. Placental abnormalities (MRI and anatomopathological study) were consistent with intense vascular malperfusion, probably the cause of fetal death. Lung histopathology also showed signs of inflammation, which could have been a contributory factor. Monitoring inflammatory response and coagulation in high-risk pregnant women with COVID-19 may prevent unfavorable outcomes, as shown in this case.</p>