AUTHOR=Denes Eric , Fiorenza Fabrice , Armendariz Mateo , Martin Christian 

TITLE=Case Report: CD8+ T-Lymphocyte Deficit: A Prerequisite for Pasteurella spp. Infection?

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.668976

DOI=10.3389/fmed.2021.668976

ISSN=2296-858X

ABSTRACT=<p><bold>Background:</bold> Immunity against <italic>Pasteurella</italic> spp. is not well-known for humans.</p><p><bold>Methods:</bold> We've tested T CD8+ lymphocytes in a patient with a chronic prosthetic joint infection due to <italic>Pasteurella</italic> spp. to search for a deficit which could have favored her infection. As this deficit was found, we've searched for such a deficit in other patients with <italic>Pasteurella</italic> spp. Infections, either acute or subacute.</p><p><bold>Results:</bold> Eight patients were tested and all had a persistent T CD8+ lymphocytes deficit. This is striking as these cells are involved in the response to this type of infection in animal models.</p><p><bold>Conclusion:</bold> The authors suggest that a deficit in CD8+ T lymphocytes can be one of the causes for the onset of infections with <italic>P. multocida</italic>.</p>