AUTHOR=Li Xian , Dong Chuning , Ma Xiaowei , Wang Yunhua 

TITLE=18F-FDG PET/CT Associates With Disease Activity and Clinical Recurrence of AOSD Patients

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.668323

DOI=10.3389/fmed.2021.668323

ISSN=2296-858X

ABSTRACT=<p><bold>Objective:</bold> The purpose of this study was to explore the value of <sup>18</sup>F-FDG PET/CT in monitoring the disease activity and predicting the prognosis of the Adult-onset Still's disease (AOSD).</p><p><bold>Methods:</bold> We retrospectively analyzed the electronic medical records of 45 AOSD patients who underwent <sup>18</sup>F-FDG PET/CT in the Second Xiangya Hospital. PET/CT imaging and clinical information were retrospectively reviewed and analyzed. <sup>18</sup>F-FDG uptake was assessed by measuring standard uptake value (SUV) in the spleen, liver, bone marrow, and lymph nodes. The spleen-to-liver ratio of the SUVmax (SLRmax) and SUVmean (SLRmean), the bone-to-liver ratio of the SUVmax (BLRmax), and SUVmean (BLRmean), and the lymph nodes-to-liver ratio of the SUVmax (LyLRmax) were calculated. Clinical and laboratory information were collected and evaluated for association with metabolic parameters of <sup>18</sup>F-FDG PET/CT. The influencing factors for recurrence within 1 year were analyzed to determine whether <sup>18</sup>F-FDG PET/CT can predict the prognosis of AOSD patients.</p><p><bold>Results:</bold> Elevated <sup>18</sup>F-FDG uptake could be observed in bone marrow, spleen, and lymph nodes of AOSD patients. Correlation analysis between <sup>18</sup>F-FDG uptake of organs and laboratory examinations showed that SLRmean positively correlated with LDH, AST, ferritin, and the systemic score (<italic>r</italic> = 0.572, 0.353, 0.586, and 0.424, <italic>P</italic> &lt; 0.05). The SLRmean had the highest correlation with ferritin (<italic>r</italic> = 0586, <italic>P</italic> &lt; 0.001). All metabolic parameters in spleen, including SUVmax, SUVmean, SLRmax, and SLRmean, are positively correlated with LDH level (<italic>r</italic> = 0.405, 0.539, 0.481, and 0.572, <italic>P</italic> &lt; 0.05). Bone marrow SUVmax, BLRmax, and BLRmean were correlated with C-reactive protein (CRP) level (<italic>r</italic> = 0.395, 0.437, and 0.469, <italic>P</italic> &lt; 0.05). Analysis of the influencing factors of recurrence within 1 year showed that the spleen SUVmax, spleen SUVmean, SLRmax, SLRmean, ferritin, and the systemic score of the recurrence group was significantly higher than the non-recurrence group (<italic>P</italic> &lt; 0.05). The SLRmean cutoff of 1.66 with a sensitivity of 72.7% and specificity of 80.0% had the highest performance in predicting recurrence.</p><p><bold>Conclusion:</bold> The glucose metabolism of the liver, spleen, and bone marrow of AOSD patients were correlated with laboratory inflammatory indicators and system score, suggesting that <sup>18</sup>F-FDG PET/CT could be applied to evaluate disease activity. Moreover, spleen <sup>18</sup>F-FDG uptake may be a potential biomarker for predicting clinical prognosis of AOSD patients.</p>