AUTHOR=Mahtal Nassim , Lenoir Olivia , Tharaux Pierre-Louis 

TITLE=Glomerular Endothelial Cell Crosstalk With Podocytes in Diabetic Kidney Disease

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.659013

DOI=10.3389/fmed.2021.659013

ISSN=2296-858X

ABSTRACT=<p>Diabetes is the main cause of renal failure worldwide. Complications of the kidney micro-and macro-circulation are common in diabetic patients, leading to proteinuria and can progress to end-stage renal disease. Across the complex interplays aggravating diabetes kidney disease progression, lesions of the glomerular filtration barrier appear crucial. Among its components, glomerular endothelial cells are known to be central safeguards of plasma filtration. An array of evidence has recently pinpointed its intricate relations with podocytes, highly specialized pericytes surrounding glomerular capillaries. During diabetic nephropathy, endothelial cells and podocytes are stressed and damaged. Besides, each can communicate with the other, directly affecting the progression of glomerular injury. Here, we review recent studies showing how <italic>in vitro</italic> and <italic>in vivo</italic> studies help to understand pathological endothelial cells-podocytes crosstalk in diabetic kidney disease.</p>