AUTHOR=Dai Tingting , Hu Qinghua , Xie Zhongshang , Li Chunhui 

TITLE=Case Report: Infective Endocarditis Caused by Aspergillus flavus in a Hemodialysis Patient

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.655640

DOI=10.3389/fmed.2021.655640

ISSN=2296-858X

ABSTRACT=<p>Fungal endocarditis (FE) is a rare but fatal disease. The incidence of infective endocarditis (IE) in hemodialysis patients with catheters is thought to be obviously higher than that in the general population. We reported a case of IE caused by <italic>Aspergillus flavus</italic> (<italic>A. flavus</italic>) in a 36-year-old woman on hemodialysis. Because the blood cultures were persistently negative, so we used mNGS (Metagenomic next generation sequencing) for early clinical diagnosis. After treatment with voriconazole, the patient's condition improved rapidly. She continued oral voriconazole treatment 1 year after discharge and is in good condition. The diagnosis and treatment strategies of FE in hemodialysis patients were discussed.</p>