AUTHOR=Qu Mengdi , Zhang Hao , Chen Zhaoyuan , Sun Xingfeng , Zhu Shuainan , Nan Ke , Chen Wankun , Miao Changhong TITLE=The Role of Ferroptosis in Acute Respiratory Distress Syndrome JOURNAL=Frontiers in Medicine VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.651552 DOI=10.3389/fmed.2021.651552 ISSN=2296-858X ABSTRACT=

Ferroptosis is a newly discovered type of regulated cell death that is different from apoptosis, necrosis and autophagy. Ferroptosis is characterized by iron-dependent lipid peroxidation, which induces cell death. Iron, lipid and amino acid metabolism is associated with ferroptosis. Ferroptosis is involved in the pathological development of various diseases, such as neurological diseases and cancer. Recent studies have shown that ferroptosis is also closely related to acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS), suggesting that it can be a novel therapeutic target. This article mainly introduces the metabolic mechanism related to ferroptosis and discusses its role in ALI/ARDS to provide new ideas for the treatment of these diseases.