AUTHOR=Xiang Pan , Xu Xinmin , Lu Xin , Gao Lili , Wang Huizhu , Li Zhenpeng , Xiong Haofeng , Li Ruihong , Xiong Yanwen , Pu Lin , Qin Tian , Jin Fangfang , Ren Hongyu , Li Chuansheng , Yang Jing , Zhang Ming , Gong Jie , Chen Xiaoping , Zheng Han , Tan Jianbo , Sun Yao , Zhao Fei , Hou Xuexin , Liu Yufeng , Guo Hebing , Hao Jingjing , Kan Biao , Zhou Haijian , Wang Yajie , Liu Jingyuan TITLE=Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction JOURNAL=Frontiers in Medicine VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.629828 DOI=10.3389/fmed.2021.629828 ISSN=2296-858X ABSTRACT=

We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and a significant increase in intracranial pressure developed in an adult coronavirus disease 2019 patient. The complete genome sequence of SARS-CoV-2 obtained from the cerebrospinal fluid indicates that SARS-CoV-2 can invade the central nervous system. In future, along with nervous system assessment, the pathogen genome detection and other indicators are needed for studying possible nervous system infection of SARS-CoV-2.