AUTHOR=Lopes Alessandra G. D. , Celestino Camila S. H. , Barros Tiago T. A. , Fevereiro Aline G. , Gejer Debora H. , Oliveira Fernando M. F. , Brasil Jamile M. , Bossolan Rosely M. , Pinto Gabriela C. C. , Santos Ana C. E. Z. , Divan Luis A. , Alves Ingrid A. B. , Oliveira Danielle B. L. , Machado Rafael R. G. , Thomazelli Luciano M. , Hiyane Meire I. , Brelaz-Abreu Leonília , Bragança-Jardim Elayne , Heinen Letícia B. S. , Barrientos Anna C. M. , Mau Luciana B. , Camara Niels O. S. , Bueno Daniela F. , Amano Mariane T. TITLE=Case Report: A Severe SARS-CoV-2 Infection in a Teenager With Angelman Syndrome JOURNAL=Frontiers in Medicine VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.629112 DOI=10.3389/fmed.2021.629112 ISSN=2296-858X ABSTRACT=

Teenagers generally present mild to no symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the present report, we present the case of a 14-year-old boy with Angelman syndrome (AS) who presented with severe COVID-19 symptoms. He spent 20 days in the ICU with elevated inflammatory biomarkers (C-reactive protein and D-dimer) and increased peaks of neutrophil-to-lymphocyte ratio, which is uncommon for teenagers diagnosed with COVID-19. Although he showed physiological instability, he was able to produce neutralizing antibodies, suggesting a functional immune response. The literature concerning the immune response to infections in patients with AS is still poor, and to our knowledge, this was the first report of a patient with AS diagnosed with COVID-19. As such, the present study may alert other patients with AS or other rare diseases that they lack a competent immune response and could suffer severe consequences of SARS-CoV-2 infection.