AUTHOR=Delcroix Olivier , Bourhis David , Keromnes Nathalie , Robin Philippe , Le Roux Pierre-Yves , Abgral Ronan , Salaun Pierre-Yves , Querellou Solène 

TITLE=Assessment of Image Quality and Lesion Detectability With Digital PET/CT System

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.629096

DOI=10.3389/fmed.2021.629096

ISSN=2296-858X

ABSTRACT=<p><bold>Purpose:</bold> The aim of this study was to assess image quality and lesion detectability acquired with a digital Positron Emission Tomography/Computed Tomography (PET/CT) Siemens Biograph Vision 600 system.</p><p><bold>Material and Methods:</bold> Consecutive patients who underwent a FDG PET/CT during the first week of use of a digital PET/CT (Siemens Biograph Vision 600) at the nuclear medicine department of the university hospital of Brest were analyzed. PET were realized using list mode acquisition. For all patients, 4 datasets were reconstructed. We determined, according to phantom measurements, an equivalent time acquisition/reconstruction parameters pair of the digital PET/CT corresponding to an analog PET/CT image quality (“analog-like”) as reference dataset. We compared the reference dataset with 3 others digital PET/CT reconstruction parameters, allowing a decrease of emission duration: 60, 90, and 120 s per bed position. Three nuclear medicine physicians evaluated independently, for each dataset, overall image quality [Maximal Intensity Projection (MIP), noise, sharpness] using a 4-point scale. Physicians assessed also lesion detection capability by reporting new visible lesions on each digital datasets with their confidence level in comparison with analog-like dataset.</p><p><bold>Results:</bold> Ninety-eight patients were analyzed. Image quality of MIP (IQ<sub>MIP</sub>), sharpness (IQ<sub>SHARPNESS</sub>), and noise (IQ<sub>NOISE</sub>) of all digital datasets (60, 90, and 120 s) were better than those evaluated with analog-like reconstruction. Moreover, digital PET/CT system improved IQ<sub>MIP</sub>, IQ<sub>NOISE</sub>, and IQ<sub>SHARPNESS</sub> whatever the BMI. Lesion detection capability and confidence level were higher for 60, 90, 120 s per bed position, respectively, than for analog-like images.</p><p><bold>Conclusion:</bold> Our study demonstrated an improvement of image quality and lesion detectability with a digital PET/CT system.</p>