AUTHOR=JAK Behling , Zanirati Gabriele , Rodrigues Felipe V. F. , Grahl Matheus , Krimberg Felipe , Pinzetta Giulia , Borém Larissa , Savi Daniela , Machado Denise Cantarelli , Da Costa Jaderson Costa , Marinowic Daniel Rodrigo 

TITLE=Case Report: Placental Maternal Vascular Malperfusion Affecting Late Fetal Development and Multiorgan Infection Caused by SARS-CoV-2 in Patient With PAI-1 4G/5G Polymorphism

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.624166

DOI=10.3389/fmed.2021.624166

ISSN=2296-858X

ABSTRACT=<p><bold>Background:</bold> Pregnant women are susceptible to the novel coronavirus (SARS-CoV-2), and the consequences for the fetus are still uncertain. Here, we present a case of a pregnant woman with subclinical hypothyroidism and a plasminogen activator inhibitor type 1 (PAI-1) 4G/5G polymorphism who was infected with SARS-CoV-2 at the end of the third trimester of pregnancy, with unexpected evolution of death of the newborn 4 days postpartum.</p><p><bold>Methods:</bold> Nested PCR was performed to detect the virus, followed by ssDNA sequencing.</p><p><bold>Results:</bold> Transplacental transmission of SARS-CoV-2 can cause placental inflammation, ischemia, and neonatal viremia, with complications such as preterm labor and damage to the placental barrier in patients with PAI-1 4G/5G polymorphism.</p><p><bold>Conclusion:</bold> We showed a newborn with several damages potentially caused due to the PAI-1 polymorphisms carried by the mother infected with SARS-CoV-2 during pregnancy.</p>