AUTHOR=Shao Mingxi , Li Yingzhu , Teng Jisen , Li Shengjie , Cao Wenjun 

TITLE=Association Between Serum Lipid Levels and Patients With Primary Angle-Closure Glaucoma in China: A Cross Sectional, Case–Control Study

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.618970

DOI=10.3389/fmed.2021.618970

ISSN=2296-858X

ABSTRACT=<p><bold>Objective:</bold> To evaluate the serum lipid levels of patients with primary angle-closure glaucoma (PACG) and to investigate the relationship between serum lipid levels and PACG.</p><p><bold>Methods:</bold> In this cross-sectional, case–control study, a total of 320 PACG subjects and 242 age- and sex-matched control subjects were recruited. Serum high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (SDLDL-C), triglyceride (TRIG), and cholesterol (CHOL) levels were measured using enzymatic colorimetry. Serum apolipoprotein A (APOA), apolipoprotein B (APOB), apolipoprotein E (APOE), and lipoprotein(a) (LPa) levels were measured by immunoturbidimetry.</p><p><bold>Results:</bold> The serum LDL-C, TRIG, HDL-C, APOE, LPa, CHOL, APOB, and APOA levels were significantly higher (<italic>p</italic> &lt; 0.05) in the PACG group than in the control group. Multiple liner regression analyses revealed that there was a statistically correlation between HDL-C levels and mean deviation MD (<italic>B</italic> = 0.389, <italic>P</italic> = 0.002, 95% confidence interval [CI] = −1.249 to −0.624); LDL-C levels and MD (<italic>B</italic> = 0.190, <italic>P</italic> = 0.019, 95% CI = −5.632 to −1.306); and CHOL levels and MD (<italic>B</italic> = 0.364, <italic>P</italic> = 0.27, 95% CI = −7.727 to −1.839). Logistic regression analyses showed that high serum HDL-C (odds ratio [OR] = 11.01, 95% CI = 5.616–21.587), LDL-C (OR = 1.330, 95% CI = 1.079–1.640), SDLDL-C (OR = 1.007, 95% CI = 1.005–1.008), APOA (OR = 13.621, 95% CI = 7.251–25.591), APOB (OR = 2.243, 95% CI = 1.060–4.732), LPa (OR = 0.999, 95% CI = 0.998–1.00), and CHOL (OR = 1.131, 95% CI = 1.005–1.326) levels were significantly associated with PACG.</p><p><bold>Conclusions:</bold> High serum HDL-C, LDL-C, APOA, APOB, LPa, and CHOL levels were associated with PACG.</p>