AUTHOR=Liu Bing , Yu Ying , Liu Wen , Deng Tuo , Xiang Daoman 

TITLE=Risk Factors for Non-arteritic Anterior Ischemic Optic Neuropathy: A Large Scale Meta-Analysis

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.618353

DOI=10.3389/fmed.2021.618353

ISSN=2296-858X

ABSTRACT=<p><bold>Objective:</bold> We conducted a meta-analysis to explore all the potential risk factors for non-arteritic anterior ischemic optic neuropathy (NAION) based on the published literature.</p><p><bold>Methods:</bold> A comprehensive literature search through the online databases was performed to obtain studies concerning the risk factors of NAION up to June 2020. Pooled unadjusted odds ratios (<italic>OR</italic>s) or rate ratios (<italic>RR</italic>s) were calculated to evaluate the weight of risk factors. This study was registered in PROSPERO under the number CRD42018084960.</p><p><bold>Results:</bold> Our meta-analysis included 49 original studies comprising of more than 10 million patients. The following risk factors were proved to be significantly associated with NAION: male gender (<italic>OR</italic> = 1.67, 95% <italic>CI</italic>: 1.50–1.85, <italic>P</italic> &lt; 0.00001), hypertension (<italic>RR</italic> = 1.28, 95% <italic>CI</italic>: 1.20–1.37, <italic>P</italic> &lt; 0.00001), hyperlipidemia (<italic>RR</italic> = 1.43, 95% <italic>CI</italic>: 1.26–1.62, <italic>P</italic> &lt; 0.00001), diabetes mellitus (DM) (<italic>RR</italic> = 1.53, 95% <italic>CI</italic>: 1.36–1.73, <italic>P</italic> &lt; 0.00001), coronary heart disease (CHD) (<italic>RR</italic> = 1.68, 95% <italic>CI</italic>: 1.24–2.27, <italic>P</italic> = 0.0008), sleep apnea (<italic>RR</italic> = 3.28, 95% <italic>CI</italic>: 2.08–5.17, <italic>P</italic> &lt; 0.00001), factor V Leiden heterozygous (<italic>RR</italic> = 2.21, 95% <italic>CI</italic>: 1.19–4.09, <italic>P</italic> = 0.01), and medication history of cardiovascular drugs.</p><p><bold>Conclusion:</bold> We concluded that the above risk factors were significantly related to NAION. Better understanding of these risk factors in NAION can help the direct therapeutic approaches.</p>