AUTHOR=Asúnsolo Ángel , Chaowen Chen , Ortega Miguel A. , Coca Santiago , Borrell Luisa N. , De León-Luis Juan , García-Honduvilla Natalio , Álvarez-Mon Melchor , Buján Julia 

TITLE=Association Between Lower Extremity Venous Insufficiency and Intrapartum Fetal Compromise: A Nationwide Cross-Sectional Study

JOURNAL=Frontiers in Medicine

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.577096

DOI=10.3389/fmed.2021.577096

ISSN=2296-858X

ABSTRACT=<p><bold>Introduction:</bold> Chronic venous disorder (CVeD) has a high prevalence, being commonly diagnosed by the presence of varicose veins. In fact, the development of varicose veins in lower extremities and/or pelvic venous insufficiency (LEPVI) is frequent. However, its potential impact on fetal health has not been investigated. This study aimed to examine whether the presence of varicose veins in women's LEPVI is related to an intrapartum fetal compromise event.</p><p><bold>Materials:</bold> A cross-sectional, national study was conducted using medical administrative records (CMBD) of all vaginal births (<italic>n</italic> = 256,531) recorded in 2015 in Spain. The independent variable was defined as the presence of varicose veins in the legs, vulva, and perineum or hemorrhoids. A logistic regression model was used to assess the association of interest.</p><p><bold>Results:</bold> Among women with vaginal deliveries, those with varicose veins in their LEPVI have a significantly greater odds of intrapartum fetal compromise (OR = 1.30, 99.55%CI = 1.08–1.54) than their counterparts without varicose veins. After adjustment, this association remained significant (OR = 1.25, 99.5%CI = 1.05–1.50).</p><p><bold>Conclusions:</bold> Our findings of an association between varicose veins in women's lower extremities and/or pelvis and intrapartum fetal compromise suggest that varicose veins may be a novel and important clinical risk factor for fetal well-being and health.</p>